Meanwhile, Derby head into this contest on the back of four victories from five matches, the latest coming against Middlesbrough at the weekend.
Ahead of the meeting with Boro on Saturday afternoon, Wayne Rooney was aware that he faced the difficult task of lifting his players after their 3-0 reverse at Rotherham United.
Having had over a week to stew on that disappointment was less than ideal for the Rams, but two first-half goals helped the club to an excellent 2-1 win over the promotion hopefuls.
For Rooney, it was justification for not over-reacting to the biggest setback of his short stint at Pride Park, and his side now sit three points clear of the relegation zone.
The England legend will now do everything possible to ensure that complacency does not become an issue, particularly with several mid-table teams beginning to falter.
The addition of Colin Kazim-Richards was heavily criticised upon his arrival earlier in the season, but the veteran now has six goals for the season after his wonder-strike on Saturday.
Facing a 2-0 deficit at Huddersfield on Saturday, Wycombe boss Gareth Ainsworth could have been forgiven for thinking that the club's season was realistically all but over.
However, the remarkable comeback has breathed new life into Wycombe's campaign, the result reducing the margin to safety to 10 points.
The Chairboys will require more than the odd result in isolation to have any chance of survival at the second tier, but overcoming the Terriers was proof that his squad of players are still giving everything to the cause.
The return from injury of Joe Jacobson could prove to be key, although the veteran left-back requires assistance from his teammates if Wycombe are to pull off the unthinkable later in the season.
Wycombe Wanderers Championship form: LLDLLW
Wycombe Wanderers form (all competitions): LLDLLW
Derby County Championship form: LWWWLW
Ainsworth could stick with the same Wycombe XI after their welcome victory at Huddersfield.
Jordan Obita is an alternative to Jacobson, who came through 73 minutes on his first appearance in almost a month.
Rooney may also feel inclined to name the team which got the better of Middlesbrough at the weekend.
Wycombe Wanderers possible starting lineup:
Allsop; Grimmer, Stewart, Tafazolli, Jacobson; Wheeler, Knight, Mehmeti; McCleary, Ikpeazu, Horgan
Derby County possible starting lineup:
Marshall; Byrne, Wisdom, Clarke, Buchanan; Waghorn, Knight, Shinnie, Jozwiak; Kazim-Richards, Gregory
We say: Wycombe Wanderers 1-2 Derby County
Wycombe will naturally be full of confidence after the scenes at the John Smith's Stadium at the weekend. Nevertheless, we feel that Derby's more measured approach will be the difference here, the visitors well equipped to edge a close match against their relegation rivals.