Meanwhile, Blues head into this fixture having recorded just one point from four matches, leaving the club in 17th position in the table.
Playing with 10 men for much of their Boxing Day fixture with Preston North End, Rooney would have been delighted with the character shown by his side throughout the fixture at Pride Park.
However, conceding a 96th-minute winner left the Rams squad deflated, and they now face the challenge of bouncing back from losing their six-match unbeaten streak under Rooney.
Although the positives will be taken from 10 points being recorded from their last seven outings, it has not been enough to keep the club outside of the bottom three.
A trip to Birmingham represents an opportunity to get back on track, but Rooney will acknowledge that suffering a second successive defeat ahead of the trip to Sheffield Wednesday would be a huge blow.
Nevertheless, Derby have performed better away from home of late, and the England legend may feel comfortable in reverting to the mindset that led to four points coming from fixtures at Millwall and Brentford.
Birmingham boss Aitor Karanka has been under pressure to play with more attacking intent with his team continuing to struggle for goals in the second tier.
While victories have recently been recorded at Bristol City and Reading, a four-match winless streak has put the Spaniard in a position where he will still have doubts about the change in mentality.
A goalless draw at Nottingham Forest on Boxing Day was a step in the right direction, but the West Midlands outfit only remain seven points above the relegation zone.
Although getting the better of Derby would ease any fears regarding a fight at the wrong end of the table, Karanka will again feel that avoiding defeat against a rival should be at the top of his priority list.
Birmingham City Championship form: WWLLLD
Derby County Championship form: DWDDWL
Karanka is unlikely to make many alterations to the Birmingham XI which started the game at the City Ground.
Derby will be without Martyn Waghorn after the forward was sent off against Preston.
Birmingham City possible starting lineup:
Etheridge; Colin, Roberts, Dean, Friend; Clayton, Sunjic; Sanchez, Toral, Bela; Hogan
Derby County possible starting lineup:
Marshall; Byrne, Wisdom, Clarke, Buchanan; Bird, Bielik, Shinnie; Holmes, Kazim-Richards, Jozwiak
We say: Birmingham City 1-1 Derby County
With both teams struggling in the final third, we would be very surprised to see many goals in this game. While Karanka and Rooney may place more focus on getting on the scoresheet, this could still end in a low-scoring share of the spoils.