The Trotters are currently on a winless run of four matches in all competitions, while a victory for fourth-placed Palace could see Ian Holloway's men move into the automatic promotion places.
Palace nicked a 1-0 victory when the two teams met at the Reebok Stadium back in September.
Meanwhile, the visitors are expected to recall a number of senior players following their midweek defeat at Stoke City in the FA Cup.
Palace: Bogdan; Alonso, Ream, Knight, Ricketts; Eagles, Andrews, Spearing, Lee; Ngog, Sordell
Bolton: Speroni; Moxey, Delaney, Ramage, Parr; Bolasie, Jedinak, O'Keefe, Moritz; Zaha, Murray
Sports Mole says: 2-0