The Argentine, who joined Palace in 2004, reached the landmark at Selhurst Park as the Eagles took a big step towards staying in the Premier League.
"It's a great achievement," Speroni told the club's official website. "It's something that, as a goalkeeper, you love to do – keep clean sheets. You are always pleased after the game if you keep a clean sheet.
"But to reach 100 of them is fantastic, really. I'm proud of that, very proud."
Palace continue their Premier League campaign on Wednesday when they make the trip to Everton.