The Portuguese coach has already made his impact since leaving Real Madrid by completing the signings of Andre Schurrle, Marco van Ginkel and Mark Schwarzer.
Below, Sports Mole has selected five players who could be making their way out of the exit door at the West London outfit.
Demba Ba only completed a move to Chelsea from Newcastle United during the January transfer window, but it appears as though he could already be ready to depart the Europa League winners.
The Senegal international has been less than prolific during his short spell in London, scoring six goals in 22 appearances.
That has resulted in Mourinho targeting an array of world-class strikers from around Europe, but he could be forced to sell before anyone arrives at the club.
Ever since his arrival at Stamford Bridge in 2006, John Obi Mikel has been a regular fixture in the centre of Chelsea's midfield.
However, the Nigerian international spent the second half of last season on the periphery of the starting lineup and that could have encouraged Mikel to seek pastures new this summer.
With Michael Essien back with the squad after a successful loan period with Real Madrid and the incoming of Van Ginkel, Chelsea need to make space in their squad and that could mean the 26-year-old being considered expendable.
Mikel was linked with a transfer to Galatasaray last month, while he would expect to attract plenty of interest with some of the major clubs in Europe.
Victor Moses became a key member of the squad at Stamford Bridge last season after joining the club from Wigan Athletic.
While he scored just once in the Premier League, he played an important role in Chelsea's run to the Europa League final.
However, after the arrival of Schurrle, Moses could soon find himself as a fringe player under Mourinho, which might see the former Crystal Palace player seek a temporary move elsewhere.
New Everton boss Roberto Martinez, under whom Moses played at Wigan, is reportedly keen on taking the Nigerian international to Goodison Park.
The future of Fernando Torres has long been a hot topic of conversation at Stamford Bridge ever since his poor form during the first 18 months after his arrival from Liverpool.
The 29-year-old netted a total of just 12 goals during that time, but he did score 22 times in 64 appearances last season.
However, despite reportedly being reassured about his future, offers in excess of £15m could be considered for the Spanish international.
That resulted in speculation of a big-money move to Barcelona, while Paris Saint-Germain were reportedly prepared to bid for the Brazilian centre-back.
Talk of a move has cooled in recent weeks, but it would come as no surprise if Europe's big names did not return with significant offers before the end of the transfer window.