A win for City would confirm their status as champions, while the Blues are yet to be assured of a top-four finish, and here Sports Mole rounds up all the latest team news for the two clubs.
Sports Mole's predicted XI: Ederson; Cancelo, Dias, Laporte, Mendy; Rodri, Gundogan, De Bruyne; Mahrez, Aguero, Sterling
Out: Mateo Kovacic (thigh)
Sports Mole's predicted XI: Mendy; Zouma, Rudiger, Christensen; James, Jorginho, Kante, Alonso; Mount, Pulisic; Havertz
Watch the Sports Mole Football Shorts prediction for this game below: