Meanwhile, the Seagulls head into the contest having moved five points clear of the relegation zone courtesy of a 2-0 triumph over Bournemouth at the weekend.
While Chelsea have been hampered by their lack of consistency since the arrival of Frank Lampard, the presence of the club legend has also played a pivotal part in the team's ability to frequently bounce back from setbacks with significant wins.
During a period where they have lost at home to Bournemouth and Southampton without troubling the scoresheet, Chelsea have recorded maximum points at the grounds of Tottenham Hotspur and Arsenal.
To some degree, witnessing his players perform with class against Spurs and sheer desire versus the Gunners will frustrate Lampard, who did not hide his disappointment after the previous defeats at Stamford Bridge.
Nevertheless, the Englishman will at least feel optimistic for the future as the club look to close the gap on second and third place, while also defending their hold on fourth position.
While achieving Champions League football for next season has become the natural priority target, Lampard will feel that this side is capable of more if they can maintain a high level over a prolonged period.
Most of the attention this season has been focused on a misfiring backline and a youthful attack, but Jorginho reiterated his importance to the team and squad in general at the Emirates Stadium on Sunday.
Despite the Italian being fortunate to remain on the pitch during the closing stages, his presence after his introduction settled the Blues down at a time when their opponents could have effectively ended the game as a contest.
The performance creates a selection dilemma for Lampard going forward, although it is one which he will like having when no-one in his squad is producing the consistency he is demanding.
Chelsea travel to the south coast having now won seven of their 10 away matches in this season's Premier League, although that record will not intimidate Graham Potter's Brighton squad.
While the Seagulls have only registered four wins at the Amex Stadium from 10 attempts, their style of play has regularly caused problems for their opponents this season, regardless of their position in the table.
That said, Brighton desperately needed their success against Bournemouth at the weekend after falling to within a defeat of being pulled into the bottom three.
There is the perception that Brighton are a team on the up under Potter, something which may be the case, but a four-match winless streak had highlighted the need for results over displays which are easy on the eye.
With more breathing space to work with, Potter will now hope that his players can replicate that performance four days later against Chelsea, who outplayed them at Stamford Bridge earlier in the campaign.
There is also the added motivation of trying to record back-to-back Premier League wins for just the second time this season - something which has not been achieved since the start of November.
Given that Chelsea have also not put together successive triumphs since October 26, the opportunity is there to get another three points on the board, which would ultimately leave Brighton not far away from the top 10.
Brighton & Hove Albion Premier League form: WDDLLW
Chelsea Premier League form: WLLWLW
Chelsea form (all competitions): LWLWLW
While Lampard is expected to switch back to four in defence, the Chelsea boss is also likely to make changes in personnel due to the short turnaround.
As for Brighton, they have had an extra day's rest, meaning that Potter could opt to keep the same starting lineup.
Brighton & Hove Albion possible starting lineup:
Ryan; Montoya, Webster, Dunk, Burn; Bissouma, Propper; Trossard, Mooy, Jahanbakhsh; Maupay
Chelsea possible starting lineup:
Arrizabalaga; Azpilicueta, Rudiger, Zouma, Palmieri; Kante, Jorginho, Kovacic; Mount, Hudson-Odoi, Abraham
Head To Head
Wednesday's meeting will represent just the 14th competitive clash between the clubs, with Chelsea registering 11 wins in comparison to just one victory for Brighton.
Remarkably, starting in 1967, Chelsea's wins have all come in succession, including five which have been played in the Premier League since December 2017.
Brighton's one and only success against the Blues came in their first-ever encounter in 1933.
We say: Brighton & Hove Albion 2-2 Chelsea
This has all the makings of an entertaining tussle, with Brighton strong in front of their own supporters and Chelsea remaining unpredictable, regardless of whether they are playing home or away. We feel that there is every chance of this contest ending level after a late goal.