Lampard has featured in all 13 of Chelsea's matches in 2013, while defender Ivanovic has missed just one.
With that in mind, Benitez has decided to give the duo the evening off.
"Frank has been playing a lot of games," Benitez told a press conference. "Managing the squad means we can keep fresh legs on the pitch."
Chelsea go into the match having won the opening leg in the Czech Republic last week 1-0.