Danish champions FC Nordsjaelland have never faced English opposition in their 21-year history.
They had also never appeared in the Champions League until this season.
Meanwhile, Cesar Azpilicueta is expected to make his first start in the Champions League for Chelsea.
Veteran midfielder Frank Lampard could also be recalled to the starting lineup.
The Blues last took on Danish opposition two years ago when they defeated FC Copenhagen 2-0 on aggregate in the last 16 of the competition.
Nordsjaelland: Hansen; Parkhurst, Okore, Runje, Mtiliga; Stokholm, Adu, Lorentzen, Christensen, John; Beckmann
Chelsea: Cech; Azpilicueta, Terry, Cahill, Bertrand; Mikel, Lampard, Mata, Hazard, Oscar; Sturridge
Sports Mole says: 1-3