The Blues should be able to welcome N'Golo Kante back from a hamstring problem, and Christian Pulisic was taken off at half time with an injury in the same area against West Bromwich Albion, but Tuchel should have him available here.
However, Jorginho and Mateo Kovacic could start in midfield if Kante is only fit enough for a spot on the bench, while Mason Mount should earn a recall to the final third as no risks are taken over Pulisic.
Hakim Ziyech was the unfortunate one to be hooked after Thiago Silva's early red card at the weekend, so the winger will hope to come back with a bang in Seville. Olivier Giroud has fond memories of his most recent trip to Ramon Sanchez-Pizjuan Stadium, and the Frenchman could lead the line over Kai Havertz and Timo Werner.
Antonio Rudiger was reportedly ejected from a training session on Sunday following a bust-up with Kepa Arrizabalaga, so the German may not be considered for a starting place even if he does travel to Seville.
Silva's red card at the weekend does not impact his participation in this game, but with him having only just returned from injury, Tuchel could elect to call upon Andreas Christensen instead.
Chelsea possible starting lineup:
Mendy; Azpilicueta, Zouma, Christensen; Hudson-Odoi, Jorginho, Kovacic, Chilwell; Ziyech, Mount; Giroud