Chelsea vs. Bayern Munich (Tuesday, 8pm)
Meanwhile, the German outfit make the trip to Stamford Bridge having maintained top spot in the Bundesliga with a hard-fought triumph against Paderborn.
We say: Chelsea 1-3 Bayern Munich
Although Chelsea are on a high after the success over Spurs, this represents a tougher challenge for the Blues. While Bayern had issues at the back on Friday, we feel that they will have too much quality for their hosts at the other end of the pitch.
Napoli vs. Barcelona (Tuesday, 8pm)
The home side have also enjoyed a strong recent run, registering three victories in all competitions to boost their chances in Serie A and the Coppa Italia.
We say: Napoli 1-2 Barcelona
Given Napoli's recent form, Barcelona should not have it all their own way on Tuesday evening. However, the visitors are starting to improve under Setien, and we feel that the Catalan outfit will return to Spain with a slender advantage.