David Goodwillie, who recently joined the Eagles on loan from Blackburn Rovers, is expected to start up front for Freedman's side. The Scot will partner Glenn Murray after his two goals during the win over Wednesday.
Meanwhile, Charlton could also give a full debut to their loan signing Ricardo Fuller.
The hosting Addicks believe that over 21,000 people will be attendance at the Valley.
Possible starting lineups:
Charlton: Hamer; Morrison, Wiggins, Solly, Cort; Jackson, Pritchard, Hollands, Haynes; Fuller, Wright-Phillips
Palace: Speroni; Delaney, Ramage, Parr, Williams; Garvan, Moxey, Jedinak, Zaha; Murray, Goodwillie
Sports Mole says: 2-1