Saturday's goalless draw at fellow promotion hopefuls Watford left Malky Mackay's side five points clear of Hull City at the top, and Tuesday's visit of the Tykes is their game in hand before the final run-in.
Mackay rested Peter Whittingham at Vicarage Road and a return to the starting lineup is likely for the midfielder. Heidar Helguson could also get a starting berth after remaining on the bench as well.
Barnsley go into the match as one of a number of clubs nearer the foot of the table who keep picking up wins to make the bottom of the division extremely volatile.
The reverse fixture back in November went Cardiff's way as they edged a three-goal contest 2-1 at Oakwell.
Possible starting lineups
Cardiff: Marshall; Taylor, Turner, Barnett, McNaughton; Conway, Mutch, Gunnarsson, Whittingham; Bellamy, Helguson
Barnsley: Steele, Hassell, Foster, Dawson, Perkins, Kennedy, Wiseman, Mellis, Etuhu, O'Grady, Scotland
Sports Mole says: 2-0