Captain Stephen McNulty is rested and replaced by Fraser Franks so Jonathan Smith skippers the side from midfield, while there are starts for Paul Connolly, Jim Stevenson, Jake Howells, Adam Drury and Ricky Miller.
Veteran midfielder Luke Chadwick starts in midfield.
Cambridge United: Dunn, Tait, Taylor, Coulson, Nelson, Donaldson, Chadwick, Champion, Hughes, Simpson Elliott.
Subs: Norris, Miller, Dunk, Atkinson, Hurst, Kaikai, Bird.
Luton Town: Tyler; Connolly, Wilkinson, Franks; Drury, Harriman; Smith, Stevenson, Howells; Cullen, Miller.
Subs: Lacey, Rooney, Ruddock, Lafayette, Robinson, Walker, Justham.