The Robins have won each of their last four home games against QPR, scoring two goals on each occasion, while the Hoops travel to Ashton Gate having picked up just one point from their last three matches.
An own goal from goalkeeper Daniel Bentley moments before half time cancelled out Tyreeq Bakinson's earlier header, before an 88th-minute winner from Cameron Carter-Vickers snatched all three points for the Cherries.
The Robins now sit just inside the top half of the Championship table, 10 points behind Bournemouth, who are currently occupying the final playoff spot.
Bristol City head into Saturday's encounter with a good record against QPR, having won each of their last six league meetings against them by an aggregate score of 12-2.
Pearson has also previously done well when managing teams against the Hoops - winning five, drawing two and losing only one of his eight league matches against them.
The Robins will be keen to move on from their first setback of the Pearson era and with nine of their next 10 fixtures against teams currently below them in the table, they will be looking to put an impressive run of form together, starting this weekend, as they aim to move into the top six.
QPR lost successive league matches for the first time since early December as they were defeated 3-1 at home to high-flying Barnsley on Wednesday night.
Charlie Austin scored his fifth goal for the Hoops since joining on loan in January, however, strikes from Daryl Dike, Alex Mowatt and Carlton Morris helped the Tykes win back-to-back league matches at Loftus Road.
Despite accumulating 19 points from a possible 24 available since the turn of the year, two defeats in five days has seen QPR slip down to 17th in the table, eight points above the relegation zone.
The Hoops have a poor record against Bristol City and are winless from their last nine meetings against them; they have also failed to win any of their previous 10 league visits to Ashton Gate.
Victory on Saturday could see QPR climb as high as 14th in the Championship, three points behind 10th-placed Millwall, who they face at Loftus Road in two weeks' time.
Bristol City Championship form: LLLWWL
Queens Park Rangers Championship form: WWWDLL
For QPR, Warburton has no injury or suspension concerns heading into Saturday's match and is unlikely to make many changes to his starting lineup despite successive league defeats.
Bristol City possible starting lineup:
Bentley; Mariappa, Vyner, Kalas; Hunt, Palmer, Nagy, Bakinson, Sessegnon; Diedhiou, Wells
Queens Park Rangers possible starting lineup:
Dieng; Dickie, Cameron, Barbet; Kane, Ball, Johansen, Wallace; Chair; Austin, Bonne
We say: Bristol City 2-1 Queens Park Rangers
Despite narrowly losing on Wednesday night, Bristol City have shown signs of improvement under Pearson and will fancy their chances of claiming three points against a QPR side looking to avoid three successive league defeats.
The Hoops have struggled in recent seasons against the Robins, and we expect the hosts to secure another victory against them at Ashton Gate this weekend.