Three teams are currently level on 26 points at the top of the Championship table, but the Rams lead the way due to superior goal difference as things stand.
That is despite a shock 2-1 defeat at the hands of Wigan Athletic last weekend, a result that handed Derby just their second loss of the season.
It looked as if Steve McClaren's side could be heading for back-to-back defeats for the first time since March when they fell 2-0 behind against Fulham in the League Cup on Tuesday, but they rallied to eventually run out 5-2 victors - the second time this season they have fired five goals past the Cottagers.
A quarter-final tie against Chelsea now awaits them in December, but for now their full focus must be on the league given how tight things are at the top.
The good news for the Rams is that they have been in imperious form on their travels recently, winning five in a row in all competitions and scoring 14 goals in the process. Indeed, they boast the best away record in the league this season, taking 14 points from a possible 21 on the road.
The emphatic nature of Derby's victory in midweek could convince McClaren to keep changes to a minimum, with Simon Dawkins likely to keep his place in the side having netted a brace.
The Rams come up against a Brentford side who have adapted fairly well to life in the second tier of English football, sitting 13th in the Championship table after 14 matches.
Consistency has been an issue for the Bees, but Mark Warburton would surely be content with picking up points here and there if it meant they finished the campaign in the same position they find themselves in now.
They come into this weekend's match without a win in three, although draws against Wigan Athletic and Sheffield Wednesday are certainly not poor results, while defeat to a rejuvenated Bolton Wanderers was not entirely unexpected.
Things look a lot brighter at Griffin Park, however, which has become something of a fortress for Brentford recently. Only Norwich have beaten the Bees there in the league this season, while 12 of their 19 points have come in front of their own fans.
The hosts have no new injury concerns this weekend, but Spaniard Jon Toral is pushing for a start having come off the bench to score against Bolton.
Possible starting lineups
Brentford: Button; McCormack, Dean, Craig, Bidwell; Odubajo, Judge, Douglas, Pritchard, Jota; Gray
Derby: Butland; Christie, Keogh, Buxton, Forsyth; Hughes, Hendrick, Bryson; Russell, Martin, Dawkins
Sports Mole says: 1-2