Afobe, who is the club's record £12m signing from Wolverhampton Wanderers, is one of three January acquisitions made by the Cherries.
Simon Francis has returned to the starting XI after serving a one-match ban in last weekend's FA Cup action, while Junior Stanislas and Matt Ritchie will provide attacking support to Afobe from the flanks.
Andy Carroll, who has scored in his last two league fixtures, will lead the line for the Hammers.
Bournemouth: Boruc; Francis, Cook, Smith, Daniels; Surman; Arter, Gosling, Stanislas, Ritchie; Afobe
Subs: Federici, Distin, O'Kane, Pugh, Grabban, Murray, Iturbe
West Ham United: Adrian; Ogbonna, Tomkins, Collins, Cresswell; Obiang, Noble, Antonio; Payet, Valencia, Carroll
Subs: Randolph, Jenkinson, Reid, Oxford, Song, Cullen, Jelavic
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