Eddie Howe's Bournemouth were more than a match for Premier League Wigan Athletic when the two sides met at the DW Stadium just over a week ago.
Despite there being two divisions between the two sides, the Cherries took the lead through Eunan O'Kane, only for Wigan to force this replay thanks to a converted penalty by Jordi Gomez.
Wigan manager Roberto Martinez made a number of changes to his team before the first match and the Spanish boss is expected to make many more at Dean Court.
One player that will certainly be out for the Latics is Ivan Ramis, who suffered a knee ligament injury at the weekend.
However, Manchester United loanee Angelo Henriquez could be given his first start in a Wigan shirt.
Having spent part of the season on the bench, Bournemouth manager Howe may well hand a start to Matt Tubbs.
The winner of this tie will travel to Macclesfield Town.
Recent form
Bournemouth: WWWWDD
Wigan: LLLWLD
Possible starting lineups:
Bournemouth: James; Francis, Cook, Elphick, Pugh; Arter, Daniels, McQuoid; O'Kane; Grabban, Tubbs
Wigan: Al Habsi; Stam, Caldwell, Figueroa; Boyce, McCarthy, McArthur, Beausejour; Maloney; Di Santo, Henriquez
Sports Mole says: 2-1
Liam Apicella
