Bologna stunned Inter Milan to take all three points with a 2-1 win at the weekend, while Sassuolo enjoyed a thrilling 4-2 victory over Lecce last time out.
Bologna fans surely would not have been expecting much from their side when they travelled to a high-flying Inter Milan team, especially with the visitors 1-0 down and one man down after the hour mark.
However, Bologna managed to produce a remarkable turnaround as second-half goals from 18-year-old Musa Juwara and 21-year-old Musa Barrow condemned Inter to a 2-1 defeat on home soil and stretched Bologna's unbeaten run to three matches.
However, Bologna still have testing fixtures against AC Milan, Napoli and Atalanta to contend with in the next couple of weeks, but their confidence ought to be sky high following their memorable win against Inter.
Meanwhile, Sassuolo are enjoying a decent spell of their own and recorded their second victory in succession over relegation-threatened Lecce on Saturday.
Roberto De Zerbi's men have now only suffered one loss since the Italian top flight returned to action, and the mid-tablers have notched up at least three goals in their last four league outings.
Indeed, two 3-3 draws with Inter and Hellas Verona respectively was followed up by a 3-1 win over Fiorentina before their triumph over Lecce, and with a total of 55 goals during the 2019-20 campaign, Sassuolo are the fifth-highest scorers in the top flight.
Only the top four sides can boast more strikes than I Neroverdi this term, and with regards to individual standings, the prolific trio of Francesco Caputo, Domenico Berardi and Jeremie Boga have all hit double figures for the campaign.
The visitors currently sit just one point behind Bologna as they occupy 10th spot, and if there is a winner on Wednesday, the victors will temporarily move up to eighth before Hellas Verona take to the pitch against Inter on Thursday.
Two goals from Caputo either side of a Boga strike gave Sassuolo a 3-1 win over Bologna when the sides last met back in November.
Bologna Serie A form: DLLWDW
Sassuolo Serie A form: WLDDWW
Ibrahima Mbaye is also struggling with a muscular problem and is unlikely to feature for the visit of Sassuolo.
As far as Sassuolo are concerned, Filip Djuricic will serve a one-match suspension after picking up his fifth booking of the season last time out.
Bologna possible starting lineup:
Skorupski; Tomiyasu, Danilo, Bani, Dijks; Dominguez, Medel, Schouten; Orsolini, Barrow, Sansone
Sassuolo possible starting lineup:
Consigli; Muldur, Santos, Ferrari, Kyriakopoulos; Locatelli, Bourabia; Berardi, Defrel, Boga; Caputo
We say: Bologna 2-2 Sassuolo
Both clubs should be brimming with confidence right now and that energy should transfer onto the pitch, with plenty of attacking talent to admire on both ends. Sassuolo's front three always guarantees goals but Bologna will feel capable of beating anyone after their victory at Inter, so we are expecting the sides to play out a four-goal thriller and walk away with a point apiece.