Hoffenheim have won their last two games 3-0, and will take confidence from beating Bayern 4-1 in the reverse fixture in September.
This period of kinder fixtures for Bayern always looked like one where the reigning champions may run away with things at the top of the Bundesliga once again, and so it has proved, with three straight wins for Hansi Flick's side giving them a significant seven-point lead at the summit.
Ominously for the rest of the league, Bayern's attacking prowess appeared to have returned in the 4-0 win at Schalke 04 on Sunday, albeit against by far the Bundesliga's worst defence.
Robert Lewandowski broke another Bundesliga record by becoming the first player ever to score in eight successive away games, with the Pole's calm finish sandwiched by two decisive Thomas Muller headers. Significantly, each of these three goals was assisted by Joshua Kimmich, highlighting the midfielder's importance to this team on and off the ball.
David Alaba wrapped up the rout with a piledriver from distance, but the Bavarians will need to be on guard against a Hoffenheim side capable of transitioning at breakneck speed.
Indeed, after a significant injury crisis contributed to a tricky period of results for Sebastian Hoeness, the 38-year-old will be delighted that his side appear to be back on track.
After all, this is a team which finished sixth last season and romped their Europa League group this season, so the ceiling is clearly much higher than they have shown in the past few months.
The biggest factor for Hoffenheim's downturn in form was undoubtedly Andrej Kramaric's prolonged absence due to COVID-19, with the forward seemingly finding top gear once again having scored four goals in the past two games.
The Croatian opened the scoring with a Panenka penalty in Saturday's 3-0 win over FC Koln before wrapping up the three points in the second half with another penalty after Christoph Baumgartner's instinctive close range finish had doubled the hosts' tally.
Hoeness will know the size of the task awaiting his side in Munich, but he is likely to treat it as a free hit now that Hoffenheim have a healthy seven-point gap of their own in terms of the cushion above recent opponents Koln, who currently occupy the relegation playoff position.
Bayern Munich Bundesliga form: WWLWWW
Bayern Munich form (all competitions): WLLWWW
Hoffenheim Bundesliga form: WLLDWW
Hoffenheim form (all competitions): LLLDWW
With the Bavarians knocked out of the DFB-Pokal, Flick is free to choose what he currently considers his strongest side. It remains to be seen whether that means Benjamin Pavard or Niklas Sule at right-back, with Sule performing admirably out of position in recent matches, with Kingsley Coman competing with Leroy Sane for a starting berth on a flank.
Bayern Munich possible starting lineup:
Neuer; Sule, Boateng, Alaba, Davies; Kimmich, Goretzka; Gnabry, Muller, Coman; Lewandowski
Hoffenheim possible starting lineup:
Baumann; Kasim, Vogt, Posch; Gacinovic, Samassekou, Rudy, John; Baumgartner; Bebou, Kramaric
We say: Bayern Munich 3-1 Hoffenheim
Hoffenheim have improved in recent matches, but are probably still missing too many key players to push Bayern all of the way.
We expect the visitors to score in defeat, though, with Kramaric likely to worry Flick after scoring a brace against his side in September.