The hosts will be looking to bounce back from defeat to Manchester City in the Champions League and prove that losing from two goals ahead was just a blip.
Hamburg started well under new coach Bert van Marwijk but have won just once in their last five league games and only twice in eight away from home.
Possible starting lineups
Bayern: Neuer; Lahm, Boateng, Dante, Alaba; Martinez; Muller, Thiago, Gotze, Ribery; Mandzukic
Hamburg: Neuhaus; Mancienne, Tah, Djourou, Jansen; Rincon, Badelj; Beister, Arslan, Van der Vaart; Lasogga
Sports Mole says: 2-0