The Bavarian side have won their last 10 straight league games, which stretches back to the start of October, and are yet to drop a point at the Allianz Arena.
After a sluggish start to the season, Frankfurt have hit something of a patch of form recently and have taken seven points from the last nine available to begin a climb up the table.
Bastian Schweinsteiger is pushing for a return to the Bayern lineup, while both Arjen Robben and Franck Ribery could sit out once more. Pep Guardiola could recall Javi Martinez to shore up his midfield.
Possible starting lineups
Bayern: Neuer; Lahm, Boateng, Dante, Alaba; Martinez; Muller, Kroos, Thiago, Shaqiri; Gotze
Frankfurt: Trapp; Jung, Russ, Zambrano, Djakpa; Schwegler, Rode; Aigner, Meier, Inui; Rosenthal
Sports Mole says: 1-3