While Olympiacos are currently bottom of Group B with just one point from their opening two fixtures, they are four points clear at the top of the Greek Superleague.
Here, Sports Mole looks at how Bayern could line up for Tuesday's showdown.
While Bayern's draw with Augsburg was frustrating, the biggest blow for Niko Kovac's side was the ruptured cruciate ligament suffered by central defender Niklas Sule.
Jerome Boateng and Ivan Perisic have recovered from their respective niggles but both are unlikely to start the game, although they could be used off the bench in the second half to keep the squad fresh.
Corentin Tolisso is likely to come into the midfield alongside Thiago Alcantara, while experienced attacker Thomas Muller looks set to start ahead of Philippe Coutinho behind the striker as the Brazilian is still working towards full fitness.
Polish striker Robert Lewandowski is expected to start up front after scoring once again at the weekend, while Kingsley Coman and Serge Gnabry should also feature from the off, with the latter looking to further his tally in this competition after netting four against Tottenham Hotspur last time round.