Leverkusen have been in impressive form since the Bundesliga resumed earlier this month, recording back-to-back away victories over Werder Bremen and Borussia Monchengladbach, scoring seven times in the process.
There has been a lot of attention on 20-year-old Kai Havertz in recent months, and the attacker has scored four times in his side's last two league matches, wearing the captain's armband on both occasions.
Leverkusen have actually won six of their last seven matches in Germany's top flight, while they have suffered just one defeat in 2020 to move themselves into the top four at this stage of the campaign.
RB Leipzig moved above them with a 5-0 success at Mainz 05 on Sunday afternoon, but Bosz's team are still in the top four, one point clear of fifth-placed Gladbach on the same number of matches.
Die Werkself have only lost one of their last eight league meetings with Wolfsburg, meanwhile, recording five wins in the process, which will surely fill their fans with confidence ahead of Tuesday night's affair.
Wolfsburg, meanwhile, also have a European battle on their hands this season as they occupy sixth position, two points clear of seventh-placed Freiburg on the same number of games (27).
There is a 13-point gap from Wolfsburg to Gladbach in fifth, but Oliver Glasner's team are currently the best of the rest, ahead of the likes of Freiburg, Schalke 04 and Hoffenheim, in the battle for a Europa League spot.
The Wolves recorded a 2-1 victory over Augsburg on their return to Bundesliga action on May 16, but they suffered a 2-0 home defeat to Borussia Dortmund on Saturday afternoon.
A trip to an in-form Leverkusen is not quite what Glasner's side would have had in mind as they attempt to return to winning ways, but they have impressively picked up 10 points from their last four away games in the Bundesliga during a strong run of form.
Leverkusen Bundesliga form: WWDWWW
Leverkusen form (all competitions): DWWWWW
Wolfsburg Bundesliga form: WWDDWL
Wolfsburg form (all competitions): WDDLWL
As for Wolfsburg, Felix Klaus is suspended after his red card against Dortmund, while Mamoudou Karamoko, Yannick Gerhardt, Joshua Guilavogui, William and Ignacio Camacho are all on the sidelines through injury.
Leverkusen possible starting lineup:
Hradecky; Weiser, S. Bender, Tapsoba, Wendell; Aranguiz, Demirbay; Bellarabi, Amiri, Diaby; Havertz
Wolfsburg possible starting lineup:
Casteels; Mbabu, Pongracic, Brooks, Roussillon; Schlager, Arnold; Steffen, Mehmedi, Brekalo; Weghorst
We say: Leverkusen 2-0 Wolfsburg
Wolfsburg have only lost one of their last eight Bundesliga matches and as mentioned, have been impressive on their travels in recent games. Leverkusen, though, have developed into a very good outfit, and we fancy the home side to pick up another three points here in relatively routine fashion.