Barca boss Ernesto Valverde also includes Clement Lenglet for his competitive debut against his former club, with the Frenchman lining up alongside Gerard Pique, who announced his retirement from international football this week.
There is also a debut for Arthur Melo in midfield, although Arturo Vidal and Malcom are forced to wait for their Barcelona bows, with the former being named amongst the substitutes alongside World Cup finalists Ivan Rakitic and Samuel Umtiti.
Sevilla, meanwhile, make nine changes from their Europa League qualifying tie against Zalgiris on Thursday with summer signing Tomas Vaclik in goal and Ever Banega the only players to keep their places in the side.
Sevilla: Vaclik; Mercado, Gomez, Kjaer, Escudero; Banega, Mesa; Navas, Sarabia, Vazquez; Muriel
Barcelona: Ter Stegen; Semedo, Pigue, Lenglet, Alba; Arthur, Busquets, Rafinha; Messi, Suarez, Dembele
Subs: Cillessen, Rakitic, Coutinho, Munir, Vidal, Umtiti, Miranda
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