The Frenchman came off the bench in the 5-0 win over Celta Vigo on Thursday but appeared to be in discomfort at the end of the game.
Ernesto Valverde played down any injury concerns relating to Dembele following the Copa del Rey clash but has opted to keep the youngster on the bench at the Anoeta.
Real Sociedad: Rulli; Odriozola, Llorente, Navas, Rodrigues; Zurutuza, Illarramendi, Prieto; Juanmi, Willian, Canales
Subs: Ramirez, Zubeldia, Januzaj, Agirretxe, Aritz, Oyarzabal, Gorosabel
Barcelona: Ter Stegen; Roberto, Pique, Vermaelen, Alba; Busquets, Rakitic, Gomes, Paulinho; Messi, L. Suarez
Subs: Cillesen, Vidal, Digne, Dembele, Mascherano, Iniesta, D. Suarez
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