With the Blaugrana able to rise to the summit with a win, Koeman remains without long-term absentees Ansu Fati and Philippe Coutinho, while Martin Braithwaite is expected to miss another couple of weeks with an ankle problem.
Griezmann will be out to score for the fourth game in a row after his brace against Villarreal, while his in-form partner Messi boasts nine goals and three assists from six Camp Nou games against Granada in La Liga.
Pedri and Frenkie de Jong will continue to man the engine room as Sergio Busquets provides some defensive stability, but one change on the right could see Sergi Roberto replace Sergino Dest - as he did at half time in the win over Villarreal.
Barcelona possible starting lineup:
Ter Stegen; Mingueza, Lenglet, Pique; Busquets; Roberto, De Jong, Pedri, Alba; Messi, Griezmann