The Catalan club, who go into the game on a run of three straight victories, could potentially move 16 points clear of rivals Real Madrid with a win.
Celta Vigo currently lie second-bottom in the table, but are only three points away from 17th-placed Real Zaragoza with a superior goal difference.
However, their current form makes for a stark contrast to their opponents', with five defeats in their last six outings.
Barcelona saw off Celta Vigo 3-1 when the teams met in November.
Celta Vigo: LLWLLL
Celta Vigo: Varas; Demidov, Tunez, Lago, Johny; Pranjic, Oubina, Fernandez, De Lucas; Bermejo, Aspas
Barcelona: Valdes; Dani Alves, Pique, Jordi Alba, Puyol; Fabregas, Xavi, Busquets; Messi, Alexis Sanchez, Pedro
Sports Mole says: 0-2