The Spanish champions are currently second in the table, three points off leaders Real Madrid, while Betis occupy 12th position with 28 points to show from their 22 fixtures.
It would be fair to say that there will be plenty of eyes on Barca during the 90 minutes, but Betis will not exactly enter the match in the best of form having won just one of their last six in the league.
Indeed, having collected just six points since December 8, the Seville outfit have dropped into 12th position in the table, some six points behind seventh-placed Villarreal.
Betis actually finished sixth in 2017-18 but only claimed 10th last term and have struggled for consistency during the current season. Sunday will certainly be a special occasion for now Barca boss Quique Setien as he returns to the club that he left in May 2019.
Setien led the team to the Europa League during his first season at the helm but will not be in the mood to hand out any favours on Sunday night due to his current side's predicament.
Betis beat Barca 4-3 when they travelled to Camp Nou in November 2018, but they have not actually overcome the Catalan giants in a home La Liga fixture since March 2008.
The Spanish champions suffered a 1-0 defeat to Athletic Bilbao in the quarter-finals of the Copa del Rey on Thursday, and it has been a turbulent week considering that Lionel Messi hit back at Eric Abidal on social media in response to the sporting director's criticism of the players.
Messi himself is currently being linked with a move away, and it would be hugely damaging for the club if they were to lose the Argentine at the end of the campaign.
Real Madrid will have the chance to open up a six-point advantage at the summit on Sunday afternoon, though, and there is simply no downplaying the importance of this particular match in Seville.
Real Betis La Liga form: DLDWLD
Real Betis form (all competitions): DWWLLD
Barcelona La Liga form: DWDWLW
Barcelona form (all competitions): WWLWWL
On-loan Barca midfielder Carles Alena is also expected to start for the Green and Whites as there is no clause preventing him from taking on his parent club.
As for the visitors, Gerard Pique will be unavailable through suspension, while as mentioned, key attackers Suarez and Dembele are both on the sidelines.
Real Betis possible starting lineup:
Robles; Emerson, Mandi, Bartra, Moreno; Alena, Gonzalez, Canales; Joaquin, Iglesias, Fekir
Barcelona possible starting lineup:
Ter Stegen; Semedo, Lenglet, Umtiti, Alba; Vidal, Busquets, De Jong; Fati, Griezmann, Messi
We say: Real Betis 1-2 Barcelona
It would certainly not be a surprise to see Betis pick up a positive result, but the Green and Whites are not in the best of form at the moment. Barca are certainly due a big result after a tough period, and we fancy the Spanish champions to record a narrow victory at the Estadio Benito Villamarin.