Ronald Koeman's side suffered a 3-1 defeat in El Clasico last weekend and are currently 12th in the table, while Alaves occupy 15th position with seven points to show from their seven league games this term.
Alaves are operating in their fifth straight season at this level of football, but they finished 16th last term, just three points outside of the relegation zone after struggling for consistency.
Los Babazorros have already lost four times in Spain's top flight this season but two wins and one draw have brought them seven points, which is enough for 15th in the table at this stage.
Pablo Machin's side will also enter this weekend's contest in good form considering that they have won two of their last three in the league, including a 2-0 success away to Real Valladolid last weekend.
Alaves have lost each of their last seven La Liga games with Barca, though, including a 5-0 defeat in the corresponding match last season. The Catalan giants actually scored nine times during their two meetings in 2019-20 and will be the heavy favourites to pick up another three points on Saturday.
Barca are currently sitting down in 12th position in the table, having picked up seven points from their first five matches of the season. They are already seven points off the top of the division but have two games in hand on early league leaders Real Sociedad.
Koeman's team have lost their last two in the league, going down 1-0 at Getafe on October 17 before suffering a 3-1 home defeat to Real Madrid in El Clasico last weekend.
The Catalan side were also held to a 1-1 draw by Sevilla on October 4, meaning that they have not actually been victorious in the league since a 3-0 success at Celta Vigo on October 1.
Barca have started their Champions League campaign in impressive fashion, however, thumping Ferencvaros 5-1 last week before recording a 2-0 victory away to Juventus on Wednesday night.
It is absolutely vital that Koeman's side return to winning ways in the league, though, ahead of their third European fixture of the campaign at home to Dynamo Kiev next week.
Alaves La Liga form: LDLWLW
Barcelona La Liga form: WWDLL
Barcelona form (all competitions): WDLWLW
The home side did not pick up any fresh issues against Valladolid, though, and it would not be a surprise to see Machin keep faith with the same XI that picked up an impressive win.
As for Barca, Marc-Andre ter Stegen, Philippe Coutinho and Samuel Umtiti remain unavailable for selection, while Ronald Araujo is expected to miss out with the thigh problem that he picked up against Juve.
Gerard Pique was suspended against the Italian champions but will come back into the XI for this game, while Ousmane Dembele could also retain his spot following an impressive display against the Old Lady.
Pedri's recent form has been excellent, and the 17-year-old should earn another start here, meaning that Antoine Griezmann could drop out to allow Ansu Fati to return. Sergio Busquets, meanwhile, is also expected to replace Miralem Pjanic in the middle of the park.
Alaves possible starting lineup:
Pacheco; Navarro, Laguardia, Lejeune, Duarte; Mendez, Pina, Battaglia, Jota; Perez, Joselu
Barcelona possible starting lineup:
Neto; Roberto, Pique, Lenglet, Alba; De Jong, Busquets; Dembele, Pedri, Fati; Messi
We say: Alaves 0-2 Barcelona
Barca's impressive performance against Juve would certainly have boosted their confidence, and Koeman's side will be determined to return to winning ways in the league. Alaves are capable of making it an uncomfortable 90 minutes, but we fancy the Catalan giants to secure all three points in routine fashion.