The Blaugrana will travel to Seville searching for their sixth La Liga win in a row, and Vilanova concedes that it will not be easy to pick up maximum points in Andalucia.
"All games are tough but it is true that the Pizjuan is not an easy ground to go to," he said. "I spent the worst 15 minutes of my life there (with Barcelona in 2009-10).
"We were 3-0 up, then it was 3-2 and they could have drawn against us even though they had 10 men.
"Sevilla are in great shape, they have conceded the fewest goals in the league (alongside Malaga with two) and it will not be easy."
Barca are currently in pole position in the league table with 15 points from five matches, two points ahead of second-placed Atletico Madrid.