Ronald Koeman's side, who are currently third in the table, five points off leaders Atletico Madrid, will again be without the services of long-term absentees Ansu Fati and Philippe Coutinho through injury.
Martin Braithwaite missed out against Getafe on Thursday due to an ankle problem, but the experienced forward could potentially be back in the squad for this match.
Ousmane Dembele was also absent from the squad against Getafe due to a slight muscular issue, but the France international trained on Friday and should therefore be in contention for this match, while the same can also be said for number two goalkeeper Neto.
Koeman is expected to resist the temptation to shuffle his pack due to the importance of the contest, with Atletico, Real Madrid and Sevilla all in the title picture.
Barcelona possible starting lineup: Ter Stegen; Mingueza, Pique, Lenglet; Dest, De Jong, Busquets, Pedri, Alba; Messi, Griezmann