Defeat for the reigning champions would all but end their hopes of retaining the crown, but Pique is confident that his team can bounce back from their Champions League quarter-final elimination by emerging victorious this weekend.
"We are human, of course something is going to affect us. On Sunday there's another big match, and we'll go there to compete and try and win. Even if we are not in our best moment, I believe we can go there and win," Pique told reporters.
Barcelona have the second-best away record in La Liga this season, although three of their four defeats during the 2016-17 campaign have come on their travels.