Gerard Pique has been declared fit to play despite reports suggesting that the defender would miss a month due to a knee injury sustained in last week's 1-1 draw at Espanyol.

Barca have also welcomed back both Sergi Roberto and Jordi Alba from the bench in the full-back positions as Ernesto Valverde's charges seek to build on their 1-0 first-leg win at Camp Nou.

Meanwhile, Philippe Coutinho and Paulinho are on the bench with Andre Gomes selected in midfield alongside Ivan Rakitic, Andres Iniesta and Sergio Busquets.

Valencia head coach Marcelino Garcia Toral has been able to recall a number of key players who missed out on the first leg as Geoffrey Kondogbia and Ezequiel Garay both return to Copa del Rey action.

The hosts will feature top scorer Simone Zaza operating alongside Luciano Vietto in attack, while playmaker Rodrigo will be operating from the left flank.

Manchester United loanee Andreas Pereira is out for three weeks, but Goncalo Guedes has made the bench despite groin trouble in recent weeks.

Valencia: Jaume; Gaya, Garay, Paulista, Montoya; Rodrigo, Kondogbia, Parejo, Coquelin; Zaza, Vietto
Subs: Neto, Vezo, Soler, Guedes, Mina, Lato, Maksimovic

Barcelona: Cillessen; Alba, Umtiti, Pique, Roberto; Iniesta, Busquets, Rakitic, Gomes; Suarez, Messi
Subs: Ter Stegen, Semedo, Coutinho, Paulinho, Alcacer, Vidal, Mina

Follow all the action from the Mestalla with Sports Mole's live match commentary.