Barcelona will take a 1-0 advantage into the second leg of the last-32 tie, with Clement Lenglet scoring the only goal of the first leg at the end of October.
Here, Sports Mole has taken a look at how a much-changed Barcelona could line up against the third-tier side on home soil.
As mentioned, Valverde will ring the changes from the clash with Villarreal on Sunday night. Ruben Semedo and Arturo Vidal are among those who could keep their spots, but there will be a number of alterations.
Carles Alena came off the bench to score against Villarreal and will start, and the 20-year-old is expected to be joined in midfield by Denis Suarez, who is in desperate need of some first-team action.
The big story could come between the sticks, with 19-year-old Inaki Pena in line to make his first-team debut as number two goalkeeper Jasper Cillessen is still struggling with a foot problem.
An extensive injury list still includes the likes of Rafinha, Sergi Roberto, Luis Suarez and Samuel Umtiti.