An all-day party has been taking place at the new, 68,000-seater Wanda Metropolitano ahead of the fixture, which sees the French striker back in the fold after a two-game ban.
Stefan Savic is left on the bench as Diego Godin and Lucas Hernandez get the nod to start in the centre of defence, with Juanfran at right-back, Filipe Luis on the left and Jan Oblak between the posts.
Fernando Torres is among Simeone's other options on the bench.
Malaga manager Michel, meanwhile, makes just two changes following the 3-1 defeat to Las Palmas on Monday, bringing in Chory Castro and Esteban Rolan for Jose Mauri and Zdravko Kuzmanovic in the midfield.
Atletico Madrid: Oblak; Juanfran, Godin, Hernandez, Filipe Luis; Niguez, Thomas, Gabi, Koke; Correa, Griezmann
Subs: Moya, Savic, Carrasco, Gaitan, Torres, Vietto, Gameiro
Malaga: Roberto; Rosales, Luis Hernandez, Diego Gonzalez, Ricca; Rolon, Recio, Mula, Chory, Adrian; Borja
Subs: Andres Prieto, Kuzmanovic, Juanpi, Cifuentes, Keko Gontan, Baysse, D. Rolan