The 4-2 win over rivals Rayo Vallecano last weekend means that Atletico are unbeaten in their last 12 league outings.
The visitors cemented their place in the top six when they thrashed Elche 4-0 on Monday.
Atletico come into this weekend's game off the back of beating Athletic Bilbao in the quarter-finals of the Copa del Rey on Wednesday.
Simeone is expected to bring David Villa back into the side after the striker was named on the substitutes' bench for the cup victory.
Sociedad coach Jagoba Arrasate has no fresh injury concerns, so could name the same XI that comfortably saw off Elche.
Atletico Madrid: WWWDDW
Real Sociedad: WWWLDW
Possible starting lineups
Atletico Madrid: Courtois; Juanfran, Godin, Miranda, Luis; Koke, Garcia, Gabi, Adrian; Costa, Villa
Real Sociedad: Bravo; C. Martinez, Ansotegi, I. Martinez, Angel; Markel, Pardo, Prieto; Vela, Agirretxe, Griezmann
Sports Mole says: 2-0