Diego Simeone's side currently sit five points clear at the top of the standings with three wins from their opening three matches.
Another victory against struggling Vienna will see the Spaniards progress with two games remaining.
In contrast, the bottom-placed visitors must win if they are to keep alive their slim hopes of making it out of the group.
Possible starting lineups
Atletico: Courtois; Juanfran, Miranda, Godin, Luis; Adrian, Gabi, Tiago, Koke; Villa, Costa
Vienna: Linder; Ortlechner, Ramsebner, Leovac, Koch; Mader, Suttner, Simkovic, Royer; Murg, Kienast
Sports Mole says: 3-0