These two clubs went up against each other in the last 16 at the beginning of 2019, with Juventus overturning a two-goal, first-leg deficit to progress further in the competition.
The Italian champions have recorded seven points from their opening three Serie A fixtures, although they were held to a goalless draw by Fiorentina at the weekend.
Here, Sports Mole predicts how Juventus may line up for the meeting with the La Liga outfit.
Maurizio Sarri is currently contending with a growing injury list at Juventus after three more players picked up issues at the weekend.
Douglas Costa and Miralem Pjanic were each withdrawn during the first half against Fiorentina with thigh and hamstring problems, while Danilo had cramp shortly after the hour mark.
Aaron Ramsey will also hope to be provided with some game time as he continues to wait for an opportunity since leaving Arsenal for Turin.