On paper at least. it appears to be a daunting trip for the Ukrainian side because Bilbao have lost just one of their last 15 home European encounters, eight of which have been won.
However, the away side can take solace from the fact that they have won six of their last seven opening group fixtures in European competition.
In terms of team selection, Athletic head coach Ernesto Valverde has no major injury concerns. Mikel San Jose and Ibai Gomez were both on the bench for the weekend's trip to Barcelona, but they could return to the starting lineup for the visit of Shakhtar.
Shakhtar have made eight previous trips to Spain, but have only won on two occasions.
Possible starting lineups
Athletic: Iraizoz; San Jose, Laporte, Gurpegi, Balenziaga; Iturraspe, Rico, Gomez; Susaeta, Muniain, Aduriz
Shakhtar: Kanibolotskiy; Srna, Ordets, Krivtsov, Azevedo; Stepanenko, Fernando; Taison, Teixeira, Costa; Adriano
Sports Mole says: 1-0