As for the visitors, they have claimed just one point from their opening two matches with Eusebio Di Francesco in the dugout.
While Atalanta defeated Torino by a 4-2 scoreline in their opening game of the season, it was a performance which did little to end suggestions that they may have peaked during the last campaign.
However, the manner of their 4-1 success over Lazio in midweek sent a clear message to their title rivals that they have the potential to build on last season's surprise top-four finish and run to the Champions League quarter-finals.
Gian Piero Gasperini will want to keep his side's feet on the ground, but that may be difficult if they maintain their free-scoring form in the final third.
After the disappointment of missing out on 100 goals in Serie A last season, there is renewed motivation to write the wrongs of their average end to the previous domestic campaign.
Although fixtures with Napoli and Inter Milan are not too far away, Atalanta have a favourable start to the season, and taking full advantage will increase the pressure on the teams around them.
As far as Cagliari are concerned, beginning 2020-21 with meetings against Sassuolo, Lazio and Atalanta represents arguably the toughest opening triple-header in the division ahead of the international break.
Di Francesco would have naturally wanted an easier bedding-in period on his return to the dugout, but he will be satisfied that a point was earned in their first fixture.
Nevertheless, he must find a way to keep this team progressing in the right direction, something which was not helped with a 2-0 reverse against Lazio.
Atalanta BC Serie A form: WW
Cagliari Serie A form: DL
Gasperini is likely to make changes to his starting XI, with Luis Muriel among the players who will be hoping for a recall.
Godin is expected to make his debut in the Cagliari defence, taking the spot of Ragnar Klavan.
Atalanta BC possible starting lineup:
Sportiello; Caldara, Palomino, Toloi; Hateboer, Freuler, Pasalic, Gosens; Gomez; Muriel, Zapata
Cagliari possible starting lineup:
Cragno; Zappa, Walukiewicz, Godin, Lykogiannis; Nandez, Marin, Rog; Pavoletti, Simeone, Pedro
We say: Atalanta BC 4-0 Cagliari
While Cagliari have performed admirably in defence, this game has one-way traffic written all over it. Providing that complacency is not an issue, expect Atalanta to cruise to victory at the weekend.