Having already confirmed their promotion to the Premier League, the Seagulls suffered a surprise 1-0 home defeat to Bristol City last weekend, allowing Newcastle United the opportunity to end today top of the pile.
There are also two changes in the back four, with Sebastien Pocognoli replacing Gaetan Bong at left-back and Chelsea loanee Fikayo Tomori coming in for Uwe Hunemeier as partner for Lewis Dunk in the heart of the defence.
For Villa, Steve Bruce makes three changes to the side that handed Blackburn Rovers a relegation lifeline with a 1-0 defeat last time out.
James Chester and Nathan Baker continue their partnership in the heart of the defence, with Neil Taylor at left-back and Sam Johnstone in goal in his final Villa appearance before returning to Manchester United.
Aston Villa: Johnstone; Bree, Chester, Baker, Taylor; Lansbury, Hourihane, Amavi, Bacuna; Adomah, Hogan
Subs: Bunn, Richards, Elphick, Gardner, O'Hare, Davis, Grealish
Brighton & Hove Albion: Stockdale; Bruno, Dunk, Tomori, Pocognoli; Knockaert, Sidwell, Stephens, Murphy; Baldock, Murray
Subs: Maenpaa, Bong, Rosenior, Kayal, Skalak, March, Hemed
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