Both sides picked up victories in their most recent fixtures, with Rennes triumphing over Nimes while Monaco overcame Nantes in gameweek three.
Rennes managed to recover from their recent friendly defeat to Benfica as they displayed their domestic credentials with a thrilling 4-2 win over Nimes.
Having notched up seven goals from three matches - a tally that is only matched by recent opponents Nimes - Rennes are currently atop the rankings courtesy of a superior goal difference over second-placed Monaco.
However, those standings are guaranteed to change with Marseille and Saint-Etienne in action later on Thursday, with the two sides having taken maximum points thus far, and one of them will knock Rennes off their perch by the close of play in midweek.
Even though Julien Stephan's side will no longer be leading the pack when they take to the field against Monaco, the early signs are promising for the Champions League contenders, who would do extremely well to better last season's third-placed ranking, and Rennes are now welcoming Monaco to a ground where they have prevailed in nine of their last 11 in the French top flight.
Monaco have also enjoyed an unbeaten start to the new campaign and are only one goal worse off than Rennes at this stage - currently occupying second spot before Marseille and Saint-Etienne lock horns on Thursday.
Niko Kovac has seen his side take seven points from a possible nine thus far, but Monaco were made to work for the win once again as they scraped a 2-1 victory over Nantes last time out.
However, 19-year-old Willem Geubbels needed just three minutes to find the back of the net after entering the field as a substitute, and Monaco held on to record a 2-1 victory in their third game of the season.
If Les Monegasques are to carry on in the same vein throughout over the next few months, Kovac's men should improve on last season's ninth-placed finish with minimal trouble as they aspire to return to European competition.
A double from Wissam Ben Yedder paved the way for a 3-2 Monaco victory when the sides met last season, and Rennes have only won twice in their last 17 matches with Les Monegasques in all competitions.
Rennes Ligue 1 form: DWW
Monaco Ligue 1 form: DWW
Rennes defender Sacha Boey will serve the third and final game of his three-match suspension here, but other than that Stephan has a fully-fit squad at his disposal for the weekend.
As for Monaco, goalkeeper Benjamin Lecomte is back in training after recovering from coronavirus and will return in between the sticks here.
Rennes possible starting lineup:
Salin; Traore, Da Silva, Aguerd, Maouassa; Camavinga, Bourigeaud, Martin; Raphinha, Guirassy, Terrier
Monaco possible starting lineup:
Lecomte; Aguilar, Disasi, Badiashile, Ballo-Toure; Tchouameni, Fofana, Diop; Martins, Ben Yedder, Onyekuru
We say: Rennes 1-2 Monaco
The pick of the fixtures in gameweek four promises to be a fascinating encounter between two sides who are only looking up at the moment. Rennes and Monaco both boast exciting young stars who are sure to take the game by storm in the next few years, but for now, we are backing Monaco's attacking prowess to steer them to victory on Saturday evening.