The hosts ended a three-game losing run with their 1-0 win at Dijon, while Saint-Etienne extended their unbeaten streak to five matches with a draw against Nimes.
Monaco boss Niko Kovac had overseen a worrying slump before Les Monegasques made the journey to Dijon, with Lille, Marseille and Lens all getting the better of this week's hosts since the start of December.
Kovac desperately needed his side to put things right against the division's basement side, and while Monaco did manage to come out on top, Kevin Volland's 15th-minute strike was all that separated the two sides at the Stade Gaston-Gerard.
Nevertheless, Les Monegasques were able to pick up a vital three points and get their European charge back on track, with Monaco managing to climb up to seventh after Lens lost at Metz, although Sang et Or do have a game in hand.
Kovac's side now find themselves two points adrift of fourth-placed Marseille, but Monaco have played two more matches than Les Olympiens, who are one of three sides that Monaco could leapfrog should results go the way of Kovac and co this week.
Despite suffering a dismal defeat to Lens in their most recent home game, Monaco have won five and drawn two of their other top-flight matches at the Stade Louis-II this term, although Les Monegasques would be making a fatal error if they were to underestimate Saint-Etienne.
While Saint-Etienne are yet to start winning on a consistent basis, Claude Puel will no doubt be pleased that his side are not succumbing to defeat every week anymore.
Les Verts would have been confident of chalking up a second successive win against a woeful Nimes outfit, but the two teams shared the spoils in a four-goal thriller at the Stade Geoffroy-Guichard, with Harold Moukoudi and Arnaud Nordin netting either side of goals from Matteo Ahlinvi and Renaud Ripart.
While that result means that Saint-Etienne can still only boast a solitary win from their last 13 in Ligue 1, Puel's side are still unbeaten in the month of December and have managed to open up a five-point gap between themselves and the bottom three.
In fact, Saint-Etienne are one of only three teams in the top flight to have not lost any of their last five matches - a record also shared by top-two sides Lille and Lyon - and Puel's men came out on top in their last away game with a 2-1 win at Bordeaux last Wednesday.
Furthermore, Saint-Etienne have managed to prevail against Monaco in their last four meetings with Les Monegasques, including a 1-0 win at the Stade Louis-II in last season's Coupe de France.
Monaco Ligue 1 form: WWLLLW
Saint-Etienne Ligue 1 form: LDDDWD
Monaco defender Axel Disasi returns to the fold for this one after his suspension against Dijon, but Kovac should stick with the same back four that kept Les Hiboux at bay on Sunday.
While Disasi is back from a ban, Youssouf Fofana will be forced to miss this one out due to an accumulation of bookings, which should see Florentino Luis start in his place with Cesc Fabregas out injured.
With regards to Saint-Etienne, Puel has a suspension of his own to contend with as Moukoudi - who opened the scoring against Nimes - will play no part on Wednesday.
Eighteen-year-old Saidou Sow could therefore partner Timothee Kolodziejczak in defence, with Bayer Leverkusen loanee Panagiotis Retsos being linked with a January return to Germany as he struggles with injury.
Monaco possible starting lineup:
Mannone; Aguilar, Maripan, Badiashile, Henrique; Martins, Florentino, Tchouameni, Diop; Ben Yedder, Volland
Saint-Etienne possible starting lineup:
Moulin; Debuchy, Sow, Kolodziejczak, Trauco; Neyou, Camara; Nordin, Aouchiche, Bouanga; Hamouma
We say: Monaco 1-1 Saint-Etienne
Saint-Etienne's unbeaten run has given the Verts faithful cause for optimism heading into 2021, but the visitors would do extremely well to claim all three points at Monaco. That being said, Puel's side boast a strong recent record against Les Monegasques, who did not look at all convincing in their narrow win at Dijon, so we can see both teams walking away with a point before the Christmas break.