The Brazilian forward has returned to training after a knee injury and will hope to build on the eight goals he has already struck against the Gunners - his best tally against a single opponent in his career - so Firmino could lead the line here.
Diogo Jota could therefore be dropped despite his winner against former club Wolverhampton Wanderers last time out, while Mohamed Salah and Sadio Mane will aim to get the better of Arsenal's pacy full-backs in the capital.
Jurgen Klopp must also take into consideration his side's battle with Real Madrid in the Champions League, but Arsenal will feel confident of overcoming anything less than a full-strength team here, so Thiago and Georginio Wijnaldum should keep their spots in midfield ahead of Curtis Jones and former Gunner Alex Oxlade-Chamberlain.
Fabinho will provide a layer of stability to the engine room now that Ozan Kabak and Nat Phillips have formed an effective centre-back pairing, as Joel Matip, Joe Gomez and Virgil van Dijk continue to recuperate from long-term injuries.
Trent Alexander-Arnold put in a good shift against Wolves, but Gareth Southgate decided that the right-back's performances this season did not warrant a place in the most recent England squad, so he will certainly hope to play a starring role at the Emirates this weekend.
Liverpool possible starting lineup:
Alisson; Alexander-Arnold, Phillips, Kabak, Robertson; Fabinho, Wijnaldum, Thiago; Salah, Firmino, Mane
Watch the Sports Mole Football Shorts prediction for this game below: