The England midfielder returned to training last month after suffering from a series of knee and ankle injuries, and manager Arsene Wenger has deemed him fit enough to make his first-team comeback against the Hoops.
Rangers boss Mark Hughes makes just one change as they bid to end their winless start to the campaign against their London rivals.
Club captain Park Ji-Sung is not included in the 18-man squad, with Shaun Wright-Phillips recalled on the right wing.
Arsenal: Mannone, Sagna, Vermaelen, Mertesacker, Santos; Arteta, Wilshere, Ramsey; Cazorla, Podolski, Giroud
QPR: Cesar, Bosingwa, Mbia, Nelsen, Traore; Wright-Phillips, Diakite, Granero, Hoilett; Taarabt; Zamora