The German international, who joined the Gunners from Real, starts for Arsene Wenger's side despite having sat out training on Friday, but Santi Cazorla misses out through injury.
Fabio Borini, who joined the Wearsiders on a season-long loan from Liverpool, is among the substitutes.
For Sunderland, Saturday's game is the start of a difficult run of home fixtures with Liverpool, Manchester United, Newcastle, Manchester City, Chelsea and Tottenham all to come.
Sunderland: Westwood, Celustka, Colback, Roberge, Diakite, Vaughan, Mavrias, Ki, Johnson, Fletcher, Altidore
Arsenal: Szczesny, Jenkinson, Gibbs, Sagna, Koscielny, Flamini, Ramsey, Wilshere, Ozil, Walcott, Giroud