The club-record signing was rested for the Gunners' goalless draw with West Ham United in midweek.
Today, Lacazette is preferred to Olivier Giroud in what is the only change made to the team by Wenger, who aims to end the North London outfit's winless run, which so far has stretched to three games in the league.
As for the visitors to the Emirates, Newcastle manager Rafael Benitez has made five changes to the side that suffered defeat at the hands of Everton in their last outing.
Arsenal: Cech; Bellerin, Koscielny, Monreal, Maitland-Niles; Iwobi, Xhaka, Wilshere; Ozil, Sanchez; Lacazette
Subs: Ospina, Chambers, Kolasinac, Coquelin, Elneny, Welbeck, Giroud
Newcastle United: Elliot; Yedlin, Lascelles, Lejeune, Manquillo; Hayden, Merino; Murphy, Perez, Atsu; Joselu
Subs: Darlow, Clark, Dummett, Diame, Aarons, Ritchie, Gayle
Follow Sports Mole's live text commentary of the match here.