Aubameyang - a January arrival from Borussia Dortmund - will start at the tip of the Arsenal attack, while Mesut Ozil and Henrikh Mkhitaryan are also included as Alexandre Lacazette is named on the bench.
As for City, head coach Pep Guardiola has made three changes to the team that started the 2-0 win over Chelsea in the Community Shield, with Ederson, Ilkay Gundogan and Raheem Sterling coming in for Claudio Bravo, Phil Foden and Leroy Sane.
Kevin De Bruyne is only fit enough for the bench this afternoon, while David Silva is again not involved. Sergio Aguero will lead the line for the Premier League champions as Gabriel Jesus is selected on the bench.
Arsenal: Cech; Bellerin, Mustafi, Sokratis, Maitland-Niles; Guendouzi, Xhaka, Ramsey; Ozil, Aubameyang, Mkhitaryan
Subs: Leno, Holding, Lichtsteiner, Elneny, Torreira, Iwobi, Lacazette
Manchester City: Ederson; Walker, Stones, Laporte, Mendy; Fernandinho, Gundogan, Bernardo; Mahrez, Aguero, Sterling
Subs: Bravo, Kompany, De Bruyne, Sane, Otamendi, Jesus, Foden
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