Wenger has used four in defence for the club's most recent fixtures, but the Frenchman has reverted to a back three with Calum Chambers coming in for his first league start of the season.
Striker Christian Benteke returns after serving a one-match ban, with James McArthur only featuring among the replacements.
Crystal Palace: Speroni; Kelly, Tomkins, Dann, Schlupp; Milivojevic, Cabaye, Loftus-Cheek; Zaha, Townsend, Benteke
Subs: Hennessey, Van Aanholt, Fosu-Mensah, McArthur, Puncheon, Riedewald, Sako
Arsenal: Cech; Chambers, Mustafi, Koscielny; Bellerin, Xhaka, Wilshere, Kolasinac; Ozil, Sanchez, Lacazette
Subs: Opsina, Walcott, Holding, Iwobi, Welbeck, Maitland-Niles, Coquelin
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